JOURNAL PUBLICATIONS 

1. Mengli Zhou, Yushu Ma, Chun-Cheng Chiang, Edwin Rock, Samuel Charles Butler, Rajiv Anne, Svetlana Yatsenko, Yinan Gong, Yu-Chih Chen, “Single-Cell Morphological and Transcriptome Analysis Unveil Inhibitors of Polyploid Giant Breast Cancer Cells In Vitro” Communications Biology, 2023 (in Press).
2. Mengli Zhou, Yushu Ma, Edwin C. Rock, Chun-Cheng Chiang, Kathryn E. Luker, Gary D. Luker, Yu-Chih Chen, “Microfluidic Single-Cell Migration Chip Reveals Insights into the Impact of Extracellular Matrices on Cell Movement,” Lab on a Chip, 23(21), 4619-4635, 2023. (cover). [Link]
3. Giuseppina Augimeri, Maria E. Gonzalez, Alessandro Paolì, Sabra Djomehri, Yu-Chih Chen, Euisik Yoon, Shantosh Karthikeyan, Sooryanarayana Varambally, Johanna M. Buschhaus, Gary D. Luker, Loredana Mauro, Daniela Bonofiglio, Sebastiano Andò, and Celina G. Kleer, “A hybrid breast cancer/mesenchymal stem cell population enhances chemoresistance and metastasis,” JCI Insight, e164216, 2023. [Link]
4. Parishmita Sarma, Carlo Marion C Carino, Deeksha Seetharama, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Xue Rui, Yubo Cao, Kouki Kawakami, Poonam Kumari, Yu-Chih Chen, Kathryn E Luker, Prem N Yadav, Gary D Luker, Stéphane A Laporte, Xin Chen, Asuka Inoue, Arun K Shukla, "Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system," Nat Commun., 14(1):4808, 2023. [Link]
5. Mishal Rao, Yu-Kai Huang, Chia-Chun Liu, Chandler Meadows, Hui-Chun Cheng, Mengli Zhou, Yu-Chih Chen, Xin Xia, Jeffrey L. Goldberg, Andrew M Williams, Takaaki Kuwajima, Kun-Che Chang, “Aldose reductase inhibition decelerates optic nerve degeneration by suppressing retinal inflammation”, Scientific Reports, 13(1), 5592, 2023. [Link]
6. Mengli Zhou, Yushu Ma, Chun-Cheng Chiang, Edwin C. Rock, Kathryn E. Luker, Gary D. Luker, Yu-Chih Chen, “High-throughput cellular heterogeneity analysis in cell migration at the single-cell level,” Small, 19(6), e2206754, 2023 (cover). [Link]
7. Emma B. Hartnett, Mengli Zhou, Yi-Nan Gong, Yu-Chih Chen, “LANCE: a Label-Free Live Apoptotic and Necrotic Cell Explorer Using Convolutional Neural Network Image Analysis,” Analytical Chemistry, 94(43), 14827-14834, 2022 (cover). [Link]
8. Parishmita Sarma, Hye-Jin Yoon, Carlo Marion C. Carino, Deeksha S, Ramanuj Banerjee, Yaejin Yun, Jeongsek Ji, Kyungjin Min, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Xue Rui, Yubo Cao, Kouki Kawakami, Poonam Kumari, Yu-Chih Chen, Kathryn E. Luker, Manish K. Yadav, Ashutosh Ranjan, Madhu Chaturvedi, Jagannath Maharana, Mithu Baidya, Prem N. Yadav, Gary D. Luker, Stéphane A. Laporte, Xin Chen, Asuka Inoue, Hyung Ho Lee, Arun K. Shukla “Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system” bioRxiv, 494935, 2022. [Link]
9. Maria E. Gonzalez, Shilpa R. Tekula, Talha Anwar, Suny Kim, Natasha Medhora, Shoshana A. Leflein, Yu-Chih Chen, Euisik Yoon, Celina G. Kleer, “EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression,” iScience, 25(8), 104827, 2022. [Link]
10. Ajai J. Pulianmackal, Dan Sun, Kenji Yumoto, Zhengda Li, Yu-Chih Chen, Meha V. Patel, Yu Wang, Euisik Yoon, Alexander Pearson, Qiong Yang, Russell Taichman, Frank C. Cackowski, Laura A. Buttitta, "Monitoring Spontaneous Quiescence and Asynchronous Proliferation-Quiescence Decisions in Prostate Cancer Cells," Front. Cell Dev. Biol., 9, 728663, 2021. [Link]
11. Sung Rye Park, Sim Namkoong, Leon Friesen, Chun-Seok Cho, Zac Zezhi Zhang, Yu-Chih Chen, Euisik Yoon, Chang H. Kim, Hojoong Kwak, Hyun Min Kang, * and Jun Hee Lee, “Single cell transcriptome analysis of colon cancer cell response to 5-fluorouracil-induced DNA damage,” Cell Reports, 32(8), 108077, 2020. [Link]
12. Brock A. Humphries, Alyssa C. Cutter, Johanna M. Buschhaus, Yu-Chih Chen, Tonela Qyli, Dilrukshika S.W. Palagama, Samantha Eckley, Tanner H. Robison, Avinash Bevoor, Benjamin Chiang, Henry R. Haley, Saswat Sahoo, Phillip C. Spinosa, Dylan B. Neale, Jagadish Boppisetti, Debashis Sahoo, Pradipta Ghosh, Joerg Lahann, Brian D. Ross, Eusik Yoon, Kathryn E. Luker, and Gary D. Luker, “Mitochondrial phenotype dictates oncogenic signaling and metastatic potential of triple negative breast cancer,” Breast Cancer Research, 22, 60, 2020. [Link]
13. Yu-Chih Chen, Zhixiong Zhang, and Euisik Yoon, “Early Prediction of Single-cell Derived Sphere Formation Using Convolutional Neural Network Image Analysis,” Analytical Chemistry, 92, 11, 7717–7724, 2020 (both the first author and senior author). [Link]
14. Yu-Chih Chen, Saswat Sahoo, Riley Brien, Seungwon Jung, Brock Humphries, Woncheol Lee, Yu-Heng Cheng, Zhixiong Zhang, Kathryn E. Luker, Max S. Wicha, Gary D. Luker, and Euisik Yoon, “Single-cell RNA-sequencing of migratory breast cancer cells: discovering drivers of cancer metastasis,” Analyst, 144, 7296 – 7309, 2019. [Link]
15. Yu-Chih Chen, Seungwon Jung, Zhixiong Zhang, Max S. Wicha, and Euisik Yoon, “Co-culture of functionally enriched cancer stem-like cells and cancer associated fibroblasts for regulator discovery using single-cell RNA-sequencing,” Integrative Biology, 11(9), 353-361, 2019. [Link]
16. Zhixiong Zhang, Lili Chen, Yimin Wang, Tiantian Zhang, Yu-Chih Chen*, and Euisik Yoon*, "Label-free Estimation of Therapeutic Efficacy on 3D Cancer Spheres Using Convolutional Neural Network Image Analysis," Analytical Chemistry, 91, 21, 14093-14100, 2019 (equally contributed senior author). [Link]
17. Yu-Chih Chen and Euisik Yoon, “Single-Cell Proteolytic Activity Measurement Using Microfluidics for Rare Cell Populations,” Methods in Enzymology, 628, 129-143, 2019. [Link]
18. Yu-Chih Chen*, Maria E. Gonzalez*, Boris Burman, Xintao Zhao, Talha Anwar, Mai Tran, Natasha Medhora, Ayse B. Hiziroglu, Woncheol Lee, Yu-Heng Cheng, Yehyun Choi, Euisik Yoon, and Celina G. Kleer, “Mesenchymal stem/stromal cell engulfment reveals metastatic advantage in breast cancer,” Cell Reports, 27, 3916–3926, 2019. [Link]
19. Yu-Heng Cheng*, Yu-Chih Chen*, Eric Lin*, Riley Brien, Yu-Ting Chen, Zhijian Hao, Woncheol Lee, Hyun Min Kang, Jason Cong, Monika Burness, Sunitha Nagrath, Max Wicha, and Euisik Yoon, “Hydro-Seq Enables Contamination-free High-throughput Single-cell RNA-sequencing for Circulating Tumor Cells,” Nature Communications, 10, 2163, 2019 (equally contributed first author). [Link]
20. Brock Humphries, Johanna M. Buschhaus, Yu-Chih Chen, Henry R. Haley, Tonela Qyli, Benjamin Chiang, Nathan Shen, Shrila Rajendran, Alyssa Cutter, Yu-Heng Cheng, Yu-Ting Chen, Jason Cong, Phillip C. Spinosa, Euisik Yoon, Kathryn E. Luker, and Gary D. Luker, “Plasminogen activator inhibitor 1 (PAI1) promotes actin cytoskeleton reorganization and glycolytic metabolism in triple negative breast cancer,” Molecular Cancer Research, 17(5), 1142-1154, 2019. [Link]
21. Zhixiong Zhang, Lili Chen, Brock Humphries, Riley Brien, Max S. Wicha, Kathryn E. Luker, Gary D. Luker, Yu-Chih Chen*, and Euisik Yoon*, “Morphological Prediction and Feature Identification of Cell Migration Using Artificial Neural Network and Random Decision Forest,” Integrative Biology, 10(12), 758-767, 2018 (equally contributed senior author). [Link]
22. Zhixiong Zhang, Yu-Chih Chen, Sumithra Urs, Diane Simeone, and Euisik Yoon, “Scalable Multiplexed Drug-Combination Screening Platforms Using 3D Microtumor Model for Precision Medicine,” Small, 14, 42, 2018. [Link]
23. Talha Anwar, Caroline Arellano-Garcia, James P. Ropa, Yu-Chih Chen, Euisik Yoon, Sierrah Grigsby, Venkatesha Basrur, Alexey Nesvizhskii, Zaneta Nikolovska-Coleska, Andrew Muntean, Maria Gonzalez, and Celina G. Kleer, “p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis,” Nature Communications, 9, 2801, 2018. [Link]
24. Rajasree Menon, Edgar A. Otto, Austin Kokoruda, Jian Zhou, Zidong Zhang, Euisik Yoon, Yu-Chih Chen, Olga Troyanscaya, Jason R. Spence, Matthias Kretzler, and Cristina Cebrián, “Single-cell analysis of progenitor cell dynamics and lineage specification of the human fetal kidney,” Development, 145(16), 164038, 2018. [Link]
25. Yu-Chih Chen, Brock Humphries, Riley Brien, Anne E. Gibbons, Yu-Ting Chen, Tonela Qyli, Henry R. Haley, Matthew E. Pirone, Benjamin Chiang, Annie Xiao, Yu-Heng Cheng, Yi Luan, Zhixiong Zhang, Jason Cong, Kathryn E. Luker, Gary D. Luker, and Euisik Yoon, “Functional Isolation of Tumor-Initiating Cells through Microfluidic-Based Cell Migration,” Scientific Reports, 8, 244, 2018. [Link]
26. Hong Sun Kim, Yu-Chih Chen, Felipe Nör, Kristy A. Warner, April Adams, Vivian P. Wagner, Manoela D. Martins, Alexander T. Pearson, Weiping Zou, Euisik Yoon, and Jacques E. Nör, “Endothelial cell-secreted IL-6 induces survival and motility of head and neck cancer stem cells,” Oncotarget, 8, 100339-100352, 2017. [Link]
27. Yu-Chih Chen*, Hyoung Won Baac*, Kyu-Tae Lee, Shamileh Fouladdel, Kendall Teichert, Jong G. Ok, Yu-Heng Cheng, Patrick N. Ingram, A. John Hart, Ebrahim Azizi, L. Jay Guo, Max S. Wicha, and Euisik Yoon, “Selective photo-mechanical detachment and retrieval of divided sister cells from enclosed microfluidics for downstream analyses,” ACS Nano, 11 (5), 4660–4668, 2017. [Link]
28. Maria E. Gonzalez, Emily Martin, Talha Anwar, Caroline Arellano-Garcia, Natasha Medhora, Arjun Lama, Yu-Chih Chen, Kevin Schmidt, Shuichi Takayama, Euisik Yoon, Kelley Kidwell, Chunxi Ge, Rafael Fridman, Renny Franceschi, and Celina G. Kleer, “DDR2 in the metastatic microenvironment is essential for stromal-cancer interactions and growth of breast cancer metastasis,“ Cell Reports, 18 (5), 1215-1228, 2017. [Link]
29. Steven G. Allen*, Yu-Chih Chen*, Julie M. Madden, Chelsea L. Fournier, Yu-Heng Cheng, Zhi Fen Wu, Liwei Bao, Joel Yates, Euisik Yoon, and Sofia D. Merajver, “Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling,” Scientific Reports, 6, 39190, 2016. (equally contributed first author). [Link]
30. Shoumei Bai, Patrick Ingram, Yu-Chih Chen, Ning Deng, Alex Pearson, Yashar Niknafs, Yun Wang, Zhong-Yin Zhang, Elisa Boscolo, Joyce Bischoff, Euisik Yoon, and Ronald Buckanovich, “EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells,” Cancer Research, 76(21), 6396-6409, 2016. [Link]
31. Yu-Heng Cheng, Yu-Chih Chen, Riley Brien, and Euisik Yoon, “Scaling and Automation of High-Throughput Single-Cell- Derived Tumor Sphere Assay Chip,” Lab Chip, 16, 3708 - 3717, 2016. (cover) [Link]
32. Yu-Chih Chen*, Zhixiong Zhang*, Shamileh Fouladdel, Yadwinder Deol, Patrick N. Ingram, Sean P. McDermott, Ebrahim Azizi, Max S. Wicha, and Euisik Yoon, “Single Cell Dual Adherent-Suspension Co-Culture Micro-Environment for Studying Tumor-Stormal Interactions with Functionally Selected Cancer Stem-like Cells,” Lab Chip, 16, 2935-2945, 2016. [Link]
33. Yu-Chih Chen*, Yu-Heng Cheng*, Patrick Ingram, and Euisik Yoon, “Single Cell Proteolytic Assays to Investigate Clonal Heterogeneity and Cell Dynamics Using an Efficient Cell Loading Scheme,” Scientific Reports, 6, 27154, 2016. [Link]
34. Yu-Chih Chen, Patrick N. Ingram, Shamileh Fouladdel, Sean P. McDermott, Azizi Ebrahim, Max S. Wicha, and Euisik Yoon, “High-Throughput Single-Cell Derived Sphere Formation for Cancer Stem-Like Cell Identification and Analysis,” Scientific Reports, 6, 27301, 2016. [Link]
35. Zhixiong Zhang*, Yu-Chih Chen*, Yu-Heng Cheng, Yi Luan, and Euisik Yoon, “Microfluidic 3D gel-island chip for single cell isolation and lineage-dependent drug response study,” Lab Chip, 16, 2504-2512, 2016. (equally contributed first author) [Link]
36. Yu-Chih Chen, Xia Lou, Zhixiong Zhang, Patrick Ingram, and Euisik Yoon, “High-Throughput Cancer Cell Sphere Formation for Characterizing the Efficacy of Photo Dynamic Therapy for 3D Cell Cultures,” Scientific Reports, 5, 12175, 2015. [Link]
37. Daniela. Burgos-Ojeda, Rong Wu, Karen McLean, Yu-Chih Chen, Moshe Talpaz, Euisik Yoon, Kathleen R. Cho, and Ronald J. Buckanovich, “CD24+ Ovarian CIC are Dependent on JAK2 Signaling for Growth and Metastasis,” Molecular Cancer Therapeutics, 14(7), 1717-27, 2015. [Link]
38. Yu-Chih Chen*, Steven G. Allen*, Patrick N. Ingram, Ronald Buckanovich, Sofia D. Merajver, and Euisik Yoon, “Single-Cell Migration Chip for Motility-based Microfluidic Selection of Heterogeneous Cell Populations,” Scientific Reports, 5, 9980, 2015. [Link]
39. Yu-Chih Chen, Tae-Hyung Kang, Patrick Ingram, Yu-Heng Cheng, and Euisik Yoon, “Osmotically actuated micro-pumps and control valves for point-of-care applications," Journal of Microelectromechanical Systems, 24(4), 982 - 989, 2015. [Link]
40. Yu-Chih Chen, Patrick Ingram, and Euisik Yoon, “Valve-less Electrolytic Isolation for Cell Co-Culture Microenvironment with Controlled Cell Pairing Ratios,” Analyst, 139, 6371-6378, 2014. [Link]
41. Yu-Chih Chen, Yu-Heng Cheng, Hong Sun Kim, Patrick N. Ingram, Jacques E. Nor, and Euisik Yoon, “Paired single cell co-culture microenvironments isolated by two-phase flow with continuous nutrient renewal,” Lab Chip, 14, 2941-2947, 2014. [Link]
42. Yoon, Hyung Ki, Lou, Xia, Chen, Yu-Chih, Koo Lee, Yong-Eun, Yoon, Euisik, Kopelman, Raoul, “Nano-photosensitizers Engineered to Generate a Tunable Reactive Oxygen Species Mix for Optimizing Photodynamic Therapy Using a Microfluidic Device,” Chemistry of Materials, 26 (4), 1592–1600, 2014. [Link]
43. Hyoung Won Baac, Jong G. Ok, Adam Maxwell, Kyu-Tae Lee, Yu-Chih Chen, A. John Hart, Zhen Xu, Euisik Yoon, and L. Jay Guo, “Carbon-Nanotube Optoacoustic Lens for Focused Ultrasound Generation and Targeted Mechanical Disruption at a Single-Cell Scale,” Scientific Reports, 2, 989, 2012. [Link]

 
CONFERENCE PAPERS

1. Mishal Rao, Yu-Kai Huang, Chia-Chun Liu, Chandler Meadows, Hui-Chun Cheng, Mengli Zhou, Yu-Chih Chen, Xin Xia, Jeffrey L. Goldberg, Andrew M Williams, Takaaki Kuwajima, Kun-Che Chang, “Aldose reductase inhibition promotes retinal ganglion cell survival after optic nerve injury”, Investig. Ophthalmol. Vis. Sci., June 2022, Vol.63;7, 1603 – A0426. (ARVO Annual Meeting) [Link]
2. Yu-Chih Chen, “Single-cell manipulation and analysis using microfluidics, photomechanical actuation, and machine learning” SPIE Photonics West, 116470M https://doi.org/10.1117/12.2575820, 2021. (Oral presentation) [Link]
3. Yu-Chih Chen, Riley Brien, Saswat Sahoo, Woncheol Lee, Yu-Heng Cheng, Seungwon Jung, Henry Haley, Kathryn Luker, Gary Luker, and Euisik Yoon, “Single-cell RNA-sequencing of migratory cancer cells sorted by microfluidics: discovering drivers of cancer metastasis,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '18), pp. 130-131, Kaohsiung, Taiwan, Nov. 2018. (Oral presentation)
4. Yu-Chih Chen, Zhixiong Zhang, Lili Chen, and Euisik Yoon, “Deep learning correlates single-cell morphology with migratory behaviors in microfluidics,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '18), pp. 331-332, Kaohsiung, Taiwan, Nov. 2018. (Oral presentation)
5. Maria E. Gonzalez*, Yu-Chih Chen*, Euisik Yoon, and Celina G. Kleer, “DDR2-depleted mesenchymal stem cells attenuate the metastasis-promoting effect of breast cancer cell engulfment of mesenchymal stem cells,” American Association for Cancer Research Annual Meeting, 176, Chicago, USA, Apr. 2018.
6. Yu-Chih Chen, Maria E. Gonzalez, Ayse Buke Hiziroglu, Xintao Zhao, Riley Brien, Yu-Heng Cheng, Zhixiong Zhang, Celina G. Kleer, and Euisik Yoon, ”Microfluidic high-throughput cell pairing and retrieval for studying breast cancer-MSC engulfment,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '17), pp. 171-172, Savannah, USA, Oct. 2017. (Oral presentation)
7. Diondra C. Harris, Alexander E. Dowell, Katrina L. Clines, Hyun Sik Moon, Charlotte A. Cialek, Alexander P. Smith, Hui Jiang, Colm Morrissey, Shi Wei, Riley J. Brien, Euisik Yoon, Yu-Chih Chen, Kathryn E. Luker, Gary D. Luker, and Gregory A. Clines, “CXCL14 is a Marker of Prostate Cancer Bone Metastasis: A Pro-Metastatic Chemokine with CXCR4 Dependent and Independent Actions,” Cancer and Bone Society Meeting, May 2017.
8. Yu-Chih Chen, Zhixiong Zhang, Yu-Heng Cheng, Euisik Yoon, and Max S. Wicha, “Microfluidic vertical adhesion-suspension co-culture platform for studying cancer stem cell-fibroblast interactions,” American Association for Cancer Research Annual Meeting, 2320, Washington D.C., USA, Apr. 2017.
9. CG Kleer, EE Martin, T Anwar, C Arellano-Garcia, A Lama, N Medhora, Y-C Chen, E Yoon, C Ge, R Franceschi, and ME Gonzalez, “Microenvironment induced DDR2 mediates stromal-cancer interactions and metastasis growth in breast cancer,” San Antonio Breast Cancer Symposium, 2016, San Antonio, Texas, USA, Dec. 2016.
10. Zhixiong Zhang, Sumithra Urs, Yu-Chih Chen, Karnik Bipin Sangani, Diane Simeone, and Euisik Yoon, “A scalable all-combination drug screening platform with one-step pipetting for cancer precision medicine,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '16), pp. 643-644, Dublin, Ireland, Oct. 2016.
11. Yu-Heng Cheng, Yu-Chih Chen, Riley Brien, and Euisik Yoon, “A 12,800-well single-cell-derived sphere assay chip utilizing highly parallelized structures for cancer heterogeneity studies,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '16), pp. 238-239, Dublin, Ireland, Oct. 2016.
12. Yu-Chih Chen, Zhixiong Zhang, Yu-Heng Cheng, and Euisik Yoon, “Single-cell transcriptome analysis to study tumor-stromal interaction on cancer-stem-cells using vertical adhesion-suspension co-culture platforms,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '16), pp. 71-72, Dublin, Ireland, Oct. 2016. (Oral presentation)
13. Yu-Chih Chen, Annie Xiao, Zhixiong Zhang, Yi Luan, Kathryn Luker, Gary Luker, and Euisik Yoon, “Microfluidic high-throughput motility-based cell selection for enriching tumor initiating cells and discovering inhibition pathways of cancer migration,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '16), pp. 49-50, Dublin, Ireland, Oct. 2016. (Oral presentation)
14. Yu-Chih Chen, Yu-Heng Cheng, Patrick Ingram, and Euisik Yoon, “Single cell proteolytic assays to investigate clonal heterogeneity and cell dynamics using efficient microfluidic cell loading,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '16), pp. 359-360, Dublin, Ireland, Oct. 2016.
15. Yu-Chih Chen, Shamileh Fouladdel, Zhixiong Zhang, Ebrahim Azizi, Euisik Yoon, and Max S. Wicha, “Single Cell Dual Adherent-Suspension Co-Culture Micro-Environment for Studying Tumor-Stormal Interactions on Functionally Selected Cancer Stem-like Cells,” American Association for Cancer Research Annual Meeting, 4076, Apr. 2016.
16. Z. Zhang, Y. C. Chen, Y. Luan, and E. Yoon, "High-throughput biomimetic 3D gel-island chip for investigating cancer cell heterogeneity," 2016 IEEE 29th International Conference on Micro Electro Mechanical Systems (MEMS), pp. 691-694, Shanghai, China, Jan. 2016.
17. Yu-Chih Chen, Hyoung Won Baac, Kyu-Tae Lee, Kendall Teichert, John A. Hart, Jay L. Guo, and Euisik Yoon, “Selective Single Cell Detachment and Retrieval for Downstream Analyses Using Nanosecond Laser Pulses in CNT-Coated Microwell Arrays,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '15), pp. 224-226, Gyeongju, Korea, Oct. 2015. (oral presentation)
18. Yu-Chih Chen, Zhixiong Zhang, and Euisik Yoon, “Dual Adherent/Suspension Co-Culture Micro-Environment for the Study of Cancer-Stromal Interactions Using Single-Cell Derived Sphere Formation,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '15), pp. 305-307, Gyeongju, Korea, Oct. 2015. (oral presentation)
19. Lou, X., Yoon, H.K., Chen, Y.C., Kopelman, R. & Yoon, E., “Characterization of nano-photosensitizer delivery and photodynamic efficacy using multicellular tumor spheroids (MCTS),” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '14), pp. 178-180, San Antonio, Oct. 2014. (Oral presentation)
20. Chelsea L. Fournier, Steven G. Allen, Yu-Chih Chen, Euisik Yoon, and Sofia D. Merajver, “Macrophage conditioned media increases the expression of a metastasis-associated oncogene, RhoC, and the migration of inflammatory breast cancer cells,” American Association for Cancer Research Annual Meeting, 1179, 2014.
21. Yu-Chih Chen, Yu-Heng Cheng, and Euisik Yoon, “Cell Niche-on-Chip: Paired Cells Co-Culture Using Oil Isolation and Semi-Permeable Membrane,” IEEE International Conference on Micro Electro Mechanical Systems, pp. 943-946, San Francisco, Jan. 2014.
22. Yu-Heng Cheng, Yu-Chih Chen, and Euisik Yoon, “High Efficiency Single Cell Capture Chip Using Herringbone Vortices for Small Sample Analysis,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '13), pp. 350-352, Freiburg, Germany, Oct. 2013.
23. Patrick Ingram, Yu-Chih Chen, and Euisik Yoon, “Polyhema Soft Lithograpy for Selective Cell Seeding, Migration Blocking, and High-Throughput Suspension Cell Culture,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '13), pp. 1451-1453, Freiburg, Germany, Oct. 2013.
24. Yu-Chih Chen, Patrick Ingram, Xia Lou, and Euisik Yoon, “Osmotic Actuation in Microfluidics for Point-of-Care Applications,” IEEE International Conference on Micro Electro Mechanical Systems, pp. 1125-1128, Taipei, Taiwan, Jan. 2013.
25. Hyoung Won Baac, Yu-Chih Chen, John Frampton, Jong G. Ok, Taehwa Lee, Kyu-Tae Lee, Euisik Yoon, Shuichi Takayama, and L. Jay Guo, “High-Precision Targeted Cell Therapy by Laser-Generated Focused Ultrasound,” SPIE Photonics West, 2013.
26. Yu-Chih Chen, Patrick Ingram, Xia Lou, and Euisik Yoon, “Single Cell Suspension Culture Using PolyHEMA Coating for Anoikis Assay and Sphere Formation,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '12), pp. 1241-1244, Okinawa, Japan, Oct. 2012. (oral presentation)
27. Yu-Chih Chen, Steven G. Allen, Zhi-fen Wu, Sofia D. Merajver, and Euisik Yoon, “Lymphatic Capillary Invasion Assay by A Single Cell Migration Chip,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '12), pp. 1032-1034, Okinawa, Japan, Oct. 2012.
28. Yu-Chih Chen, X. Lou, P. Ingram, and E. Yoon, “Cell Pairing Ratio Controlled Micro-Environment with Valve-less Electrolytic Isolation,” IEEE International Conference on Micro Electro Mechanical Systems, pp. 792-795, Paris, France, Jan. 2012.
29. Yu-Chih Chen, Xia, Lou, Patrick Ingram, and Euisik Yoon, “Single Cell Migration Chip Using Hydrodynamic Positioning,” International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '12), pp. 1409-1411, Seattle, Oct. 2011. (oral presentation)
30. S.-I. Chang, K. Al-Ashmouny, M. McCormick, Y.-C. Chen, and E. Yoon, “BioBolt: A Minimally-Invasive Neural Interface for Wireless Epidural Recording by Intra-Skin Communication,” Symposium on VLSI Circuits, pp. 146-147, Kyoto, Japan, June 2011
31. Chen Y, Khwa WSV, and Yu MHV, “Fault detection and fault tolerant design for microfluidic based biochips,” Proc of EIASC. 1–8, 2010.

 
INVITED PRESENTATIONS

1. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” Great Lakes Breast Cancer Symposium, Morgantown, WV, USA, Sep. 2023.
2. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” UPMC Hillman Cancer Center Seminar Series, Pittsburgh, PA, USA, Jan. 2023.
3. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” Cancer Biology Program Retreat, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Oct. 2022.
4. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” Department of Mechanical Engineering, National Taiwan University, Taipei, Taiwan, July. 2022.
5. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, July. 2022.
6. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan, July. 2022.
7. “Single-cell manipulation and analysis using microfluidics, photomechanical actuation, and machine learning” SPIE Photonics West, San Francisco, CA, USA, Mar. 2021. (invited talk)
8. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” Cancer Biology Program/ Women’s Cancer Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Dec. 2020.
9. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” Center for Single-Cell Omics (CSCOmics) at Shanghai Jiao Tong University School of Medicine, Shanghai, China, Jul. 2020.
10. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” Tsinghua-Berkeley Shenzhen Institute, Shenzhen, China, Jun. 2020.
11. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” Michigan State University, East Lansing, MI, USA, May. 2020.
12. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” Virginia Polytechnic Institute and State University, Blacksburg, VA, USA, Apr. 2020.
13. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA, Apr. 2020.
14. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Apr. 2020.
15. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” National Taiwan University College of Medicine, Taipei, Taiwan, Apr. 2020.
16. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” Zhejiang University, Hangzhou, China, Mar. 2020.
17. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” University of Michigan – Shanghai Jiao Tong University Joint Institute, Shanghai, China, Mar. 2020.
18. “Multi-Dimensional Comprehensive Single-Cell Analysis for Cancer Precision Medicine,” Nanyang Technological University, Singapore, Feb. 2020.
19. “Single-Cell Functional Transcriptome and Morphological Analyses Using Machine Learning for Cancer Precision Medicine,” Iowa State University, Ames, IA, USA, Jan. 2020.
20. “Single-Cell Functional Transcriptome and Morphological Analyses Using Machine Learning for Cancer Discovery,” University of Cincinnati, Cincinnati, OH, USA, Dec. 2019.
21. “High-throughput and Contamination-free Microfluidics for Single-cell RNA-sequencing of Rare Circulating Tumor Cells,” Case Western Reserve University, Cleveland, OH, USA, Oct. 2019.
22. “Single-Cell Functional Transcriptome and Morphological Analyses Using Machine Learning for Cancer Precision Medicine,” Invited Presentation in Microfluidics in Biomedical Sciences Training Program, University of Michigan, Ann Arbor, MI, USA, Oct. 2019.
23. “Single-Cell Functional Transcriptome and Morphological Analyses Using Machine Learning for Cancer Discovery,” School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, United States, Dec. 2018.
24. “Single-Cell Functional Transcriptome and Morphological Analyses Using Machine Learning for Cancer Discovery,” Institute of Chemistry, Department of Electronics of Engineering at National Chiao Tung University, Hsinchu, Taiwan, Nov. 2018.
25. “Single-cell RNA-sequencing of migratory cancer cells sorted by microfluidics: discovering drivers of cancer metastasis,” International Conference on Miniaturized Systems for Chemistry and Life Sciences, Kaohsiung, Taiwan, Nov. 2018.
26. “Deep learning correlates single-cell morphology with migratory behaviors in microfluidics,” International Conference on Miniaturized Systems for Chemistry and Life Sciences, Kaohsiung, Taiwan, Nov. 2018.
27. “Single-Cell Functional Transcriptomic and Morphological Analyses Using Machine Learning for Cancer Discovery,” Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Jul. 2018.
28. “Single-Cell Functional Transcriptomic and Morphological Analyses Using Machine Learning for Cancer Discovery,” Department of Precision Instruments, Tsinghua University, Beijing, China, Jul. 2018.
29. “Single-Cell Functional Transcriptomic and Morphological Analyses Using Machine Learning for Cancer Discovery,” Shanghai Center for Systems Biomedicine, Shanghai, China, Jun. 2018.
30. “Microfluidic high-throughput cell pairing and retrieval for studying breast cancer-MSC engulfment,” International Conference on Miniaturized Systems for Chemistry and Life Sciences, Savannah, Georgia, USA, Oct. 2017.
31. “Single Cell Analyses Enabling Discovery in Cancer Biology,” Invited Presentation in Department of Mechanical Engineering, National Central University, Taoyuan, Taiwan, March. 2017.
32. “Single Cell Analyses Enabling Discovery in Cancer Biology,” Invited Presentation in Department of Mechanical Engineering, National Taiwan University, Taipei, Taiwan, March. 2017.
33. “Single Cell Analyses Enabling Discovery in Cancer Biology,” Invited Presentation in Microfluidics in Biomedical Sciences Training Program, University of Michigan, Ann Arbor, MI, USA, Feb. 2017.
34. “Single-cell transcriptome analysis to study tumor-stromal interaction on cancer-stem-cells using vertical adhesion-suspension co-culture platforms,” International Conference on Miniaturized Systems for Chemistry and Life Sciences, Dublin, Ireland, Oct. 2016.
35. “Microfluidic high-throughput motility-based cell selection for enriching tumor initiating cells and discovering inhibition pathways of cancer migration,” International Conference on Miniaturized Systems for Chemistry and Life Sciences, Dublin, Ireland, Oct. 2016.
36. “Comprehensive Single Cell Assay Chips for Study of Cancer Heterogeneity and Metastasis,” Invited Presentation in Microfluidics in Biomedical Sciences Training Program, University of Michigan, Ann Arbor, MI, USA, 2015. (the best Post-Doctoral Speaker Award of the year)
37. “Comprehensive Single Cell Assay Chips for Study of Cancer Heterogeneity and Metastasis,” Invited Presentation in Institute of Microelectronics, Peking University, Beijing, China, 2015.
38. “Comprehensive Single Cell Assay Chips for Study of Cancer Heterogeneity and Metastasis,” Invited Presentation in Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan, 2015.
39. “Selective Single Cell Detachment and Retrieval for Downstream Analyses Using Nanosecond Laser Pulses in CNT-Coated Microwell Arrays,” International Conference on Miniaturized Systems for Chemistry and Life Sciences, Gyeongju, Korea, Oct. 2015.
40. “Dual Adherent/Suspension Co-Culture Micro-Environment for the Study of Cancer-Stromal Interactions Using Single-Cell Derived Sphere Formation,” International Conference on Miniaturized Systems for Chemistry and Life Sciences, Gyeongju, Korea, Oct. 2015.
41. “Microfluidic Single Cell Assays,” Invited Presentation in Agilent Technologies Inc. CA, USA, 2014.
42. “Comprehensive Single Cell Assay Chips for Study of Cancer Heterogeneity and Metastasis,” Invited Presentation in Lurie Nanofabrication Facility Symposium, University of Michigan, Ann Arbor, MI, USA, 2014.
43. “Comprehensive Single Cell Assay Chips for Study of Cancer Heterogeneity and Metastasis,” Invited Presentation in Physics Graduate Student Symposium (PGSS), University of Michigan, Ann Arbor, MI, USA, 2014.
44. “Characterization of nano-photosensitizer delivery and photodynamic efficacy using multicellular tumor spheroids (MCTS),” International Conference on Miniaturized Systems for Chemistry and Life Sciences, San Antonio TX, USA, Oct. 2014.
45. “Single Cell Suspension Culture Using PolyHEMA Coating for Anoikis Assay and Sphere Formation,” International Conference on Miniaturized Systems for Chemistry and Life Sciences, Okinawa, Japan, Oct. 2012.
46. “Single Cell Migration Chip Using Hydrodynamic Positioning,” International Conference on Miniaturized Systems for Chemistry and Life Sciences, Seattle, WA, USA, Oct. 2011.

 
BOOK CHAPTERS

1. Yu-Chih Chen, Seungwon Jung, Yehyun Choi, and Euisik Yoon, "Single-Cell Transcriptome Sequencing Using Microfluidics." In Dr. Fan-Gang Tseng and Dr. Tuhin Subhra Santra (ed.) Handbook of Single Cell Technologies. Springer, https://doi.org/10.1007/978-981-10-4857-9_42-1.
2. Yu-Chih Chen and Euisik Yoon, “Cell sphere high-throughput cancer formation for 3D cell culture.” In Dr. Zuzana Koledova (ed.) 3-D Cell Culture: Methods and Protocols. Chapter 18, 281-291, Springer.
3. Yu-Chih Chen, Patrick Ingram, Yi Luan, and Euisik Yoon, "Single Cell Behavioral Assays for Heterogeneity Studies." In Dr. Fan-Gang Tseng and Dr. Tuhin Subhra Santra (ed.) Essential of Single Cell Analysis. Chapter 1, Springer-V​erlag.